Colorectal Clinic London Treatment may only be provided in the context of a research study. Patients must have an active clinical diagnosis of cancer-related Cachexia/Sarcopenia and/or Appetite loss or storage symptom including but not limited to profound unintentional weight loss +/- Wasting Syndrome AND have failed standard management, which includes standard nutritional support for weight/fluid recovery within three months before enrolment in the study.
Second, all participants must meet study-specific criteria when considering enrolling into a Colorectal Clinic London research protocol. The purpose of these criteria is to ensure that patients with a range of tumor characteristics and disease studies are represented in the study.
Requirement for Completion of Prior Therapy
All patients must have completed their prior anti-cancer treatment, including surgery, radiotherapy, and chemotherapy. Additionally, if a patient is on maintenance chemotherapy, they must be free from toxicity or disease progression during the time of enrolment into Colorectal Clinic London’s clinical trial. Furthermore, if the patient underwent bone marrow transplantation previously, he/she will need to obtain documented evidence from their treating physician confirming that there has been no relapse event within six months before enrollment.
Other Requirements for Enrolment in Clinical Trials: Diagnostic Testing and Histology Reports Requirement for Patients Enrolling into Clinical Trials:
All admittance and eligibility information collected from patients will be recorded and assessed by qualified research personnel to determine whether or not the patient qualifies for entry into a clinical study. This process is known as “enrolment” in Colorectal Clinic London’s studies. Patients will undergo diagnostic tests (e.g., laboratory, electrocardiogram [ECG], X-ray) to ensure they do not have conditions that could interfere with their participation in the study; such as high levels of liver enzymes which would prevent them from taking colchicine, which is often used in colorectal cancer studies. If there are concerns about the results of any diagnostic test, an oncologist may decide to cancel the enrolment of that patient into their clinical trial. Patients will then be given an option to participate in another research study or wait for results to clarify whether they should be enrolled. Additionally, patients will also need to show proof (in the form of a copy) of histology reports provided by other treating physicians, including confirmation of diagnosis and spread. For example, if colorectal cancer has spread, it is documented as “metastatic” or “regional.”
Patients must also provide written consent before taking part in any trials at Colorectal Clinic London.